The island of Vis is the most distant larger island in the group of the Central Dalmatian islands. It is located 45 kilometres off the mainland and separated from the island of Hvar by the 18-kilometre broad Channel of Vis. The area of the island is 90,3 km2 whereas the Vis archipelago (Palagruža, Biševo, Sv. Andrija, Budihovac, Jabuka, Brusnik and others) has the area of approximately 103 km2. This makes Vis the largest district in Croatia. The coastline of Vis is 77 km long. Regular car-ferry services connect Vis with the island of Hvar and Split throughout the year and with Ancona on the Italian coast in the summer.

The largest communities on the island are Vis on the eastern side and Komiža on the western side of the island. The villages of Podselje, Marinje Zemlje, Podšpilje, Podhumlje, Podstrašje and some others are situated in the interior of the island.

The island of Vis belongs to the least populated regions of the Republic of Croatia, and 85% of the total population live in Vis and Komiža.